Felt B2
Zipp 404's are probably the most popular race wheel in this current time. They are aero, light, and fast and they work in every condition.
I'm guessing you are looking at the complete bike, which comes with 404's???
I've heard good things about the bike from people who ride it. It's a little long in the top tube camparitively to other bikes in the same range. If you have a longer torso comparitively to your legs than that would probably be a good pick for you. If you're more legs, like me, than someting with a shorter top tube would be in order. The owner of my LBS, who I ride with often on the shop rides, has the 07 B2 and really likes it. The bike isn't as stiff as some others, but I'm not sure that realy matters unless you are a track sprinter and you put out 1000 watts.
So after my blabbering, It's a good bike, it's pretty aero, and the wheels are top notch also. You should make sure you fit on the bike before you go buy it though. That's a lot of cash to be uncomfortable.
I have an 04 B2 and love it
If you get a flat, and don't have a tube, Suck it up and run it in!!!

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does anyone have input on a 2006 Felt B2?? And thoughts on Zipp 404's??